In May 2017, Dr. Xiaoyou Wang in our laboratory published litureature “Anisotropy in shape and ligand-conjugation of hybrid nanoparticulates manipulates the mode of bio-nano interaction and its outcome”on the top academic magazine in the field of functional materials, for the first time investigating simultaneously shape anisotropy, ligand-modification anisotropy and how cell phagocytosis influence nano biological interactions. It has laid a good foundation for nanoparticulates manipulating nano-bio interaction. The paper has been published in the form of inside back cover article in August 18th, 2017.
In an attempt to manipulate the biological features of nanomaterials via both anisotropic shape and ligand modification, four types of nanoparticulates with good morphological stability are designed and engineered, including hybrid nanospheres, nanodiscs, and nanodiscs with edge modification or plane modification of octa-arginine (R8) sequence. It is found that the R8 modification anisotropy can trigger huge differences in the endocytosis, intracellular trafficking, and even tissue penetration of nanoparticulates. From plane modification to edge modification of R8, the maximum increase in cell uptake is up to 17-fold, which is much more significant than shape anisotropy alone. On the other hand, six types of different cell lines are investigated to simulate biological microenvironment. It is demonstrated that the maximum difference in cell uptake among six cell lines is 12-fold. Three main driving forces are found to contribute to such bio-nano interactions. Based on the findings of this study, it seems possible to manipulate the biointeraction mode of nanomaterials and its output by regulating their anisotropy in both shape and ligand modification.
Authors: Xiaoyou Wang, Li Lin, Renfa Liu, Min Chen, Binlong Chen, Bo He, Bing He, Xiaolong Liang, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Zhifei Dai*, Qiang Zhang*
Published in Advance Functional Materials, May, 2017
See full text: http://onlinelibrary.wiley.com/doi/10.1002/adfm.201700406/epdf